Phylogenetic Applications of HLA Class II Loci

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Phylogenetic Applications of HLA Class II Loci

Human Leukocyte Antigen (HLA) loci widely known for their role in generation of immune responses are often considered to be effective in reconstructing human phylogenies due to high degree of polymorphism and rarity of recombination observed at HLA loci. In the present study, we have made an attempt to substantiate the phylogenetic potential of HLA class II loci by analyzing DRB1, DQA1 and DQB1...

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HLA Class I and Class II Genes Distribution of the Sistanis in Iran

Background: The high polymorphism in the human leukocyte antigen (HLA) genes can be used as an identity of individuals to compare with other populations. This extreme polymorphism in the HLA system is accountable for the differences in alleles and haplotypes among ethnic groups, populations, and the inhabitants of many regions. Objective: To define the frequency of HLA alleles and haplotypes am...

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Background: Pulmonary tuberculosis (PT) is one of the endemic diseases in Iraq, and among the suggested predisposing factors are alleles of the human leukocyte antigen (HLA) system. We sought to investigate the association between HLA-class I (A and B) and -class II (DR and DQ) alleles in a sample of PT Iraqi patients.Methods: lymphocytes of 105 PT patients and 40 controls were phenotyped for H...

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مطالعه وابستگی الل‌های ژن‌های HLA-class II ((HLA-DRB/DQA1/DQB1 و سرطان پستان

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ژورنال

عنوان ژورنال: INTERNATIONAL JOURNAL OF HUMAN GENETICS

سال: 2007

ISSN: 0972-3757,2456-6330

DOI: 10.31901/24566330.2007/07.02.01